Greener Generic Drug Manufacturing – Biotransformation for a Sustainable Supply Chain

Greener Generic Drug Manufacturing – Biotransformation for a Sustainable Supply Chain

Wednesday, October 29, 2025 12:15 PM to 12:40 PM · 25 min. (Africa/Abidjan)
Hall 12.1 - 12.1C68
Future of Pharma & Ingredients
FormulationMarket Insights

Information

As pharmaceutical companies push toward bold sustainability goals, transforming manufacturing processes for generic drugs is becoming a vital focus. While advancements in energy efficiency, packaging reduction, and logistics play a role, the most meaningful environmental impact may be found further upstream in cleaner, more sustainable approaches to material sourcing and production.

Emerging technologies like biocatalysis, synthetic biology, and fermentation-based methods present compelling alternatives to conventional chemical synthesis. These biotransformation techniques can significantly lower environmental footprints, improve process efficiency, and enhance scalability. However, broader adoption faces hurdles including technical barriers, cost implications, and regulatory complexity.

Siegfried AGSiegfried is a preferred partner for complete integrated Drug Substance and Drug Product services with production capabilities worldwide. Creating, improving and manufacturing formulations is our passion. Our professionalism is pivotal for your project throughout the entire life cycle. Our offering, the combination of inherited technical know-how and expertise, is unique for a supplier of development and manufacturing services. Our Drug Substance services include Custom Development and Contract Manufacturing for both APIs and intermediates. In addition, we offer a multiclient API portfolio (including controlled substances) with drug master files and patented technologies. Our Drug Product clients benefit from a broad spectrum of dosage forms and technologies like oral solids, inhalative products, opthalmics and sterile ointments. Drug Product services include Custom Development and Contract Manufacturing for the dosage forms mentioned above. Siegfried enhanced its Drug Product capabilities with the acquisition of two Novartis sites near Barcelona and the establishment of a center of excellence for developing and optimizing formulations. Thus, we expanded our competency with high potent Drug Product development and manufacturing down to an OEL of 1Mug/m3, next to capsules with APIs (down to 0.1 Mug/m3). Complex oral drug delivery systems or solubility increasing of APIs (e.g. nanomilling or spray drying) belong to our core competences. In the field of steriles, we are experienced with fill and finish of vaccines and biologic compounds. Furthermore, we can offer dry powder inhalator capsules. Siegfried has 11 GMP approved sites worldwide spanning both the eastern and western hemispheres. Our Drug Substance sites are located in Zofingen (Switzerland), Pennsville (US), Nantong (China), Minden (Germany), Evionnaz (Switzerland) and St. Vulbas (France). Our Drug Product locations are in H...

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