Innovation in Green and Low-Carbon Tech for Industry Sustainability

Green chemistry and low-carbon technologies, including continuous flow chemistry and biocatalysis, contribute significantly to sustainable pharmaceutical manufacturing. PharmaBlock's innovative approaches in this field, recognized by the 2023 and 2024 ACS CMO Excellence in Green Chemistry Awards, demonstrate how these technologies drive sustainability advancements in API synthesis.

The award-winning project in 2023 was for the innovative continuous process, involving decarboxylation, decolorization, extraction, and separation, for producing 3-oxocyclobutane-1-carboxylic acid. The award-winning project in 2024 highlights the pioneering work on continuous oxidation and reductive amination reactions at the manufacturing scale by leveraging micropacked bed technology, and manufacturing tert-butyl 3-oxoazetidine-1-carboxylate and one of its intriguing derivatives tert-butyl 3-aminoazetidine-1-carboxylate. These compounds serve as raw materials or key intermediates for many marketed drugs.

Key discussion points include

1) Optimising sustainability from improved environmental performance of raw materials and RSMs

2) Technical challenges in flow technology implementation

3) The environmental impact of these innovative technologies.