Podcast Episode 3: Spray Drying - Formulation Approaches and Technologies

Spray drying is used in various pharmaceutical applications and has become an increasingly popular technique in the production of formulations of poorly soluble APIs and inhalable dry powder formulations. This remarkable technology involves spraying a liquid formulation onto a surface which is then allowed to dry to produce a powder in one single step.

In pharmaceutical manufacturing, spray drying is suited to the production of peptides, proteins or poorly water-soluble APIs, particularly antibiotics, because it allows them to be co-processed with solubility enhancement excipients. Another advantage is that the approach reduces the number of unit operations, potentially lowering manufacturing costs.

This podcast explores how spray drying can overcome the problem of low aqueous solubility that all too often stall clinical testing programmes.