Overcoming QS-21 Supply Constraints: A Scalable GMP Approach for Global Vaccine Preparedness

The global demand for adjuvanted vaccines necessitates a robust, scalable supply of QS-21 for pandemic preparedness. This presentation outlines the strategic partnership between Indena and Desert King, structured to resolve historical supply constraints of Quillaja saponaria derivatives. We will analyze the methodologies utilized to overcome both biomass availability and processing bottlenecks. Additionally, the session will detail Indena's operational role as the industrial CDMO partner, demonstrating the successful scale-up of a highly complex extraction and chromatographic purification process under full GMP compliance, supported by an in-depth analytical characterization and thorough quality control. This collaboration guarantees a secure, commercial-scale supply chain for critical vaccine adjuvants.