Purolite A430MR Cholestyramine

Purolite A430MR is Cholestyramine, a strong base type 1 anion exchange resin powder with a polystyrene matrix and quaternary ammonium functional groups. This pharmaceutical grade product is an active drug for reducing blood cholesterol levels. The normal function of bile salts, secreted by the gall bladder into the intestines, is to emulsify fats and other lipids in order to promote their enzymatic hydrolysis and thereby enable transfer to the liver, via the venous circulation or the portal system. The bile salts, mainly sodium glycocholate, with smaller amounts of sodium taurocholate, act as surfactants by virtue of their dual lipophile/hydrophile character. In obstructive jaundice, there is an excess of these materials in the gastro-intestinal tract, increasing the concentration of cholesterol in the bloodstream, with accompanying hazard to the cardio-vascular system. A430MR has high affinity for glycocholate and taurocholate ions in bile acids, binds to them, and removes them.