Multi-dose nasal spray pumps find their place in chronic therapies, but not in acute applications. When the device use is punctual, repriming might be needed before use. Also, a large volume of a drug content could be wasted as it’s a one-off usage. Consequently, novel therapies are starting to emerge with a precise, ready-to-use unit-dose nasal spray for systemic target applications. UniSpray is a ready-to-use primeless nasal device with accurate single-metered liquid dose delivery. It offers one-handed activation with 360° functionality for emergency lifesaving and crisis treatments. Thanks to its ergonomic design, it is intuitive and easy-to-use. UniSpray is a unidose system concept under development, designed to be robust and compatible with existing marketed primary containers. We can assure reliability and full regulatory compliance of our unidose concept.