(R)-1,2-di-O-octadecenyl-3-trimethylammonium propane chloride

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Cationic lipid used in the preparation of liposomes and lipoplexes. Specifically, R-DOTMA chloride with its positive charge allows the protective loading of nucleic acids into lipid nanoparticles and promotes their endosomal release. Merck as the solely manufacturer of DOTMA-Cl can provide you with high-purity commercial material for your needs.
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Contract Development and Manufacturing Organisations (CDMOs) and Contract Manufacturing Organisations (CMOs)
MERCKMerck is a leader in life science. Our integrated offering supports all stages of pharma and biopharmaceutical manufacturing from process and formulation materials, single-use manufacturing, filtration, process development, process analytical technologies, to contract manufacturing services - all with extensive regulatory documentation. Our CTDMO services provide a streamlined experience in a single partner for mAbs, HPAPIs, ADCs, mRNA, and LNP formulation. Our standalone contract testing and analytical development services ensure the safety of the world's therapeutics. Visit https://www.sigmaaldrich.com/DE/en

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