Shielding lipids play a crucial role in prolonging circulation time and enhancing the stability of LNPs by preventing opsonization and rapid clearance. Traditionally, PEG-lipids have been used for this purpose, but concerns around immunogenicity and tolerability have driven the search for better solutions.
At Curapath, we offer a range of PEG alternatives as shielding lipids, including different Poly(2-oxazolines) (PAOx), Polysarcosines (including functionalized versions), and PGA-diol, all recommended substitutes to overcome PEG limitations and unlock new formulation possibilities.
You may find all options at : https://resources.curapath.com/en/curapath-product-catalog
