Applied R&D in Organometallics in Flow

The use of organometallic reagents based on zinc and magnesium (Grignard reagents) has been one of the most effective methods of C-C bond formation for more than 100 years.The majority of the reagents is used in the pharmaceutical industry. Metal activation, undesirable side reactions, and high exothermicity are among the most common batch challenges. Our approach allows your chemistry to reach its full potential Especially the actual organometallic reagent formation can benefit immensely from continuous process control. The ultimate goal of our work is to generate reactive intermediates such as Grignard reagents or organometallic compounds based on zinc in-situ under continuous processing conditions and, after quality control, to convert them directly in a subsequent step.