Acetal-Linkage Releasable PEGs

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NOF has developed releasable PEG derivatives that have cleavable acetal linkers in physiological environment(pH7.4). The PEGylated drug by releasable PEGs release native drug through hydrolysis and 1,4-elimination.The release rate of bioactive substance can be controlled with linker structures.
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Emulsifying/Solubilising Agents
NOF CORPORATION623NOF CORPORATION is the leading commercial supplier of GMP grade activated PEGs, lipids and ultrapure Polysorbates 80 for drug delivery products through R&D to commercial scale. We provide a wide range of lipids (ionizable, PEG, and phospho) for lipid nanoparticle formulations (LNP). Our LNP platform, containing our ionizable lipid (COATSOME(R) SS Series), has excellent endosomal escape ability and provides high gene expression with low toxicity. It is capable of applying to gene delivery, gene editing, and RNA vaccine application under this platform.

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