Activated PEG-Lipids for Targeting Lipid Nanoparticles

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For specific delivery, nanoparticles modified with ligands are widely used.Conventional modifying agents, such as activated PEG-phospholipids, have an ioniccharge.It is complicated to apply them to lipid nanoparticles (LNP), as they have anegative impact on a charge and stability of LNP.NOF newly developed non-charged PEG-lipids with active groups Activateddiacylglycerol-PEG . The lipids can introduce ligands on LNP without influence on thecharge of LNP. This feature is effective for targeting LNP aiming for nucleic acid delivery.
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NOF CORPORATION623NOF CORPORATION is the leading commercial supplier of GMP grade activated PEGs, lipids and ultrapure Polysorbates 80 for drug delivery products through R&D to commercial scale. We provide a wide range of lipids (ionizable, PEG, and phospho) for lipid nanoparticle formulations (LNP). Our LNP platform, containing our ionizable lipid (COATSOME(R) SS Series), has excellent endosomal escape ability and provides high gene expression with low toxicity. It is capable of applying to gene delivery, gene editing, and RNA vaccine application under this platform.

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