COATSOME SS Series_Novel Lipid Nanoparticle Platform

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We have newly developed COATSOME(R) SS Series foreffective intracellular delivery and lower toxicity.COATSOME(R) SS Series contains dual sensing motifs thatcan respond to the intracellular environment; tertiaryamines respond to an acidic compartment (endosome/lysosome) for membrane destabilization, and disulfidebond that can cleave in reductive environment (cytoplasm).These two units synergize for efficient intracellular deliveryof encapsulated drugs with enhanced biosafety.
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NOF CORPORATION623NOF CORPORATION is the leading commercial supplier of GMP grade activated PEGs, lipids and ultrapure Polysorbates 80 for drug delivery products through R&D to commercial scale. We provide a wide range of lipids (ionizable, PEG, and phospho) for lipid nanoparticle formulations (LNP). Our LNP platform, containing our ionizable lipid (COATSOME(R) SS Series), has excellent endosomal escape ability and provides high gene expression with low toxicity. It is capable of applying to gene delivery, gene editing, and RNA vaccine application under this platform.

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