Bio2Amine for Mesalazine (mesalamine)

Mesalazine (mesalamine, 5-aminosalicylic acid) Pharmaceutical indicated for ulcerative colitis, Crohn's disease, inflammatory bowel disease. For the reduction of 5-nitrosalicylic acid (5-NSA), Bio2Amine(TM) facilitates highly selective hydrogenation to 5-aminosalicylic with no observable intermediates or side products. HydRegen is pioneering a technology, Bio2Amine(TM), that enables slot-in biocatalytic alternatives to traditional catalysts for nitro-to-amine reduction, removing the need for precious metals for hydrogenation reactions. Bio2Amine(TM) is a cofactor-free, heterogeneous biocatalyst that has been shown to fully convert nitro to amine for over 50 compounds with excellent functional group tolerance (e.g. unsaturated bonds, halogens, sulphur).