Developing Coated Large Volume Plungers for Auto-injector and Wearable Devices

Large-volume auto-injectors and wearable devices exceeding 2.25ml play a crucial role in the transition from hospital-based intravenous (IV) treatments to self-administration via subcutaneous (SC) injection.

These devices are pivotal across various medical fields such as oncology, immunology, and neurodegenerative diseases, where they are often tasked with delivering high-viscosity and delicate biologics.

Ensuring the highest standards of quality and purity in elastomers, along with flawless functional performances, is imperative to guarantee the reliability of administration and patient safety.

In this presentation, we will delve into the technical hurdles encountered in designing and manufacturing larger coated plungers for pre-filled syringe (PFS) and cartridge containers intended for device integration.

We will showcase our journey in conceptualizing and refining these new plungers, as well as evaluating their performance throughout the entire value chain to the patient.

Additionally, we will underscore the significance of fostering an open collaboration with the container manufacturer and among the additional stakeholders involved in the development of the final combination product.